SEMELHANÇA DE ALIMENTOS FUNCIONAIS E BIOMATERIAIS COMRELAÇÃO À TOLERÂNCIA IMUNOLÓGICA
Palavras-chave:
alimentos funcionais, biomateriais, imunologia, sinergia, tolerânciaResumo
Apesar de suas diferentes naturezas e utilizações, os alimentos funcionais e os biomateriais apresentam importante semelhança no que tange a suas interações com o sistema imune. Neste ensaio teórico, descrevemos os principais mecanismos bioquímicos e efeitos fisiológicos dos alimentos funcionais relacionados à saúde humana, e comparamos sua forma de ação com a dos biomateriais. Os efeitos dos alimentos funcionais compreendem desde atividades antioxidantes, modulação de enzimas de detoxificação de agentes carcinogênicos, diminuição da agregação de plaquetas sanguíneas, alterações no metabolismo do colesterol e redução da pressão arterial, até o controle das concentrações de hormônios esteróides e do metabolismo endócrino, atividades antimicrobianas, atividades imunoestimulantes e antiinflamatórias. Sugerimos uma semelhança no modo de atuação destes alimentos e de nova geração de biomateriais na dependência de sua interação com o sistema imune, apontando para a possibilidade de uma utilização sinérgica.
Referências
ANDERSON, J.M. Foreign body reaction to biomaterials. Sem Immunol. 20: 86–100, 2008.
ANDERSON, J.M. Multinucleated giants cells. Curr Opinion Hematol, v.7, p.40-47, 2000.
ANDERSON, J.M. Biological responses to materials. Annual Rev Materials Res, v. 31, p.81-110, 2001.
ANDERSON, J.M. The future of biomedical materials. J Materials Sci: Materials Med, v.17, p.1025-1028, 2006.
ANDRADE, J.L. et al. Lectin-induced nitric oxide production. Cel Immunol. 194: 98-102, 1999.
ARAI, S. Studies on functional foods in Japan: State of the art. Biosci Biotechnol Biochem, v.60, p.9-15, 1996
ASSREUY, A.M.S., et al. Anti-inflammatory effect of glucose-mannose binding lectins isolated from Brazilian beans. Mediat Inflamm, v.6, p. 201-10, 1997.
AZEVEDO, J.C., et al. Avaliação da biocompatibilidade de implantes mamário de silicone esterilizados por calor a seco e pelo óxido de etileno. Braz J Pharm Sci. 42: 259-263, 2006
BANDT, M.D., et al. Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis. Arthritis Rheum, v. 46, p.522 532, 2002.
BARRY, K., et al. Gastrointestinal mucosal immunity. J Allergy Clin Immunol, v. 121, p.S380-3, 2008.
BEVERLEY, P.C., GRUBECK-LOEBENSTEIN, B.P. Is immune senescence reversible Vaccine, v.18, p.1721-1724, 2000.
BIASCO, G., PAGANELLI, G.M. European trials on dietary supplementation for cancer prevention. Ann NY Acad Sci, v. 889, p. 152-159, 1999.
BLOCH, A., THOMSON, C.A. Position of the American Dietetic Association: phytochemicals and functional foods. J Am Dietet Assoc, v. 95, p. 493-6, 1995.
BUTTRISS, J. Is Britain ready for FOSHU? Nutr. Bull., London, v.25, p.159-161, 2000.
CANO, P.G., et al. Adjuvant effects of Lactobacillus casei added to a renutrition diet in a malnourished mouse model. Biocell ,v. 26, p. 35-48, 2002.
CHUN, S.S; et al. Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. , v.16, p. 2-7, 2004.
COOLS, N., et al. Regulatory T Cells and Human Disease. Clin Develop Immunol, v.272, p.3-7, 2007.
CRAIG, W., BECK, L. Phytochemicals: health protective effects. Can J Diet Pract Res, v.60, p. 78-84, 1999.
DOLE FOOD Co, Mayo Clinic and University of California. Encyclopaedia of Foods, 2002.
FERNANDES, G., et al. Modulation of antioxidant enzymes and programmed cell death by n3 fatty acids. Lipids, v. 31 (Suppl): 91S-6S, 1996.
FERNANDEZ, E., et al. Fish consumption and cancer risk. Am J Clin Nutr., v.70, p. 85 90, 1999.
FERRARI, C.K.B. Oxidação lipídica em alimentos e sistemas biológicos: mecanismos gerais e conseqüências nutricionais e patológicas. Rev Nutr., v.11, p. 3-14, 1998.
FERRARI, C.K.B., TORRES, E.A.F.S. Novos compostos dietéticos com propriedades anticarcinogênicas. Rev Bras Cancerol., v.48, p. 375-382, 2002.
FERRARI, C.K.B., et al. Bioquímica e Patologia dos Radicais Livres e das Reações Peroxidativas e Mecanismos de Defesa Antioxidante. Rev Cient Farmácia e Saúde, v. 1(1), p. 40-8, 2003.
FERRARI, C.K.B., TORRES, E.A.F.S. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed Pharmacother, v. 57, p. 251-60, 2003.
FERRARI, C.K.B. Functional Foods, Herbs, and Nutraceuticals: Towards Biochemical Mechanisms of Healthy Aging. Biogerontology, v.5, p. 275-89, 2004.
FERRARI, C.K.B. Bioquímica dos Alimentos Funcionais, Nutrição e Saúde. Nutr Profis., v.1, p. 21-8, 2005.
FERRARI, C.K.B. Functional Foods and Physical Activities in Health Promotion of Aging People. Maturitas;, v.58, p. 327-39, 2007.
FERRARI, C.K.B. Diet, Herbs, and Nutritional Protection against oxidative stress in
Neurological Diseases. In: Qureshi GA, Parvez SH (Org.). Oxidative Stress and Neurodegenerative Disorders. Amsterdam: Elsevier p.525-41, 2007.
FLOCH, M.H., HONG-CURTISS, J. Probiotics and functional foods in gastrointestinal disorders. Cur Gastroenterol Rep., v.3, p. 343-350, 2001.
HÄNNINEN, O., et al. Antioxidants in vegan and rheumatic disorders. Toxicology , v.155, p.45-53, 2000.
HARDY, G. Nutraceuticals and functional foods: introduction and meaning. Nutrition, v.16, p. 688-9, 2000.
HELMUS, M,.N. e TWEDEN, K. Encydopedic handbook of biomaterials and
bioengineering: Materials selection, Donald L. Wise (1995), p. 27-59.
HUGHES, D.A. Dietary antioxidants and human immune function. Nutr Bull., v.25, p. 35-41, 2000.
ICHINOSE, Y., et al. Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. J Lab Clin Med., v.131, p. 410-8, 1998.
JANA, U., et al. Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc., Vitex negundo Linn., Tinospora cordifolia (Willid) Miers in albino rats. Ind J Pharmacol., v.31, p. 232-3, 1999.
KAO, W.K. Evaluation of protein-modulated macrophage behavior on biomaterialsp. designing biomimetic materials for cellular engineering. Ind J Antimicrobial Agents.,v.10,p..11–21, 1998.
KAPPLER, J.W., ROEHM, N., MARRACK, P. T cell tolerance by clonal elimination in the thymus. Cell., v.49, p. 273–280, 1987.
KIKUSAKI, H., NAKATANI, N. Antioxidant effect of some Ginger constituents. J Food Sci, v.58, p. 1407-1410, 1993.
KIM, H.W., et al. Screening of edible Japanese plants for suppressive effects on phorbol esterinduced superoxide generation in differentiated HL-60 cells and AS52 cells. Canc Let., v.176, p. 7-16, 2002.
KISIELOW, P., et al. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+thymocytes, Nature, v.333, p.742–746, 1988.
KLEINER, S.M. Defense plants: foods that fight disease. Physic Sportsmed, v. 25; p.12, 1997.
KREFT, I., et al. Rutin content in buckwheat (Fagopyrum esculentum Moench) food
materials and products. Food Chemistry, v.98,p. 508–512, 2006.
KROEMER, G., ZITVOGEL, L. Death, danger, and immunity: an infernal trio. Immunol Rev., v.220, p. 5-7, 2007.
KUIPERS, E.J., NICHETTI, P. Bacteria and mucosal inflammation of the gut: lessons from Helicobacter pylori. Helicobacter., v.10, p.66-70, 2005
LAMPE, J.W. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr., v.70, p. 475-90, 1999.
LANGENBACH, R., et al. Cyclooxigenase-deficient mice. A summary of their characteristics and susceptibility to inflammation and carcinogenesis. Ann NY Acad Sci., v.889, p. 52-61, 1999.
Li, Y., et al. Protein array method for assessing in vitro biomaterial-induced cytokine expression. Biomaterials, v.26, p.1 081–5, 2005.
LINOS, H., et al. Dietary factors in relation to rheumatoid arthritis: a role for olive oil and cooked vegetables? Am J Clin Nutr., v.70, p. 1077-82, 1999.
LOR, X., et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clin Nutr., v.22, p. 71-9, 2003.
LUTTIKHUIZEN, D.T. et al Cellular and molecular dynamics in the foreign body reaction. Tissue Engin, v.12, p.1955-1970, 2006.
MATTILA, P., et al. Functional properties of edible mushrooms. Nutrition, v.16, p. 694-6, 2000.
MEYDANI, S.N., Ha W-K. Immunologic effects of yogurt. J Nutr., v.71, p. 861-72, 2000.
MORENO, J.J., et al. Olive oil decreases both oxidative stress and the production of
arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages.J Nutr., v.131, p. 2145-9, 2001.
PALMER, E. Negative selection-clearing out the bad apples from the T-cell repertoire, Nat Rev Immunol., v.3, p.383–391, 2003.
PAN, P.Y., et al. Advancements in immune tolerance. Adv Drug Deliv Rev., v.60, p. 91–105, 2008
PATIST, A., ZOERB, H. Preservation mechanisms of trehalose in food and biosystems. Colloids and Surfaces B: Biointerfaces, v. 40, p. 107–113, 2005.
POLLONIO, M.A.R. Alimentos funcionais: as recentes tendências e os aspectos de segurança envolvidos no consumo. Hig. Aliment., v.14, p. 26-31, 2000.
RAMIREZ-TORTOSA, M.C., et al. Extra-Virgin Olive Oil Increases the Resistance of LDL
to Oxidation More than Refined Olive Oil in Free-Living Men with Peripheral Vascular Disease. J Nutr., v.129, p. 2177-83, 1999.
REIFEN, R. Vitamin A as an anti-inflammatory agent. Proc Nut Soc., v.61, p. 397–400, 2002.
SADLER, M. Nutritional properties of edible fungi. Nutr Bull, v.28, p. 305-308, 2003.
SATO T. and Miyata G. The nutraceutical benefit, Part II: Ginseng. Nutrition, v.16, p. 391-2, 2000.
SANTOS, L.A., et al. Influence of polymeric assitives on the mechanical properties of atricalcium phosphate cement. Bone, v.25, p. 99-102, 1999.
SCHENK, M., MUELLER, C. The mucosal immune system at the gastrointestinal barrier. Best Pract Res Clin Gastroenterol., v.22, p.391-409, 2008.
SCHUBERT, S.Y., et al. Antioxidant and eicosanoid enzyme inhibition properties of
pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol., v.66, p. 11-7, 1999.
SHARMA, R.A. e BROWNING, M.J. Mechanisms of the self/non-self-survey in the defense against cancer. Potential for chemoprevention? Crit Rev Oncol/Hematol., v.56, p.5-22, 2005.
STACY, S., et al. Immunological memory and late onset autoimmunity. Mech Ageing Develop., v.123, p. 975–985, 2002.
STARR, T.K., Positive and negative selection of T cells. Ann Rev Immunol., v.21, p.139– 176, 2003.
TOKIWA, Y. , et al. Biological production of functional chemicals from renewable resources. Canadian Journal of Chemistry, v.86, p. 548-555, 2008.
UKAWA, Y., et al.Angiotensin I-converting enzyme inhibitory activity and antitumor activity of Hatakeshimeji (Lyophyllum decastes Sing.). J Japn Soc Food Sci Technol., v.48, p. 58-63, 2001.
VENKATRAMAN, J.T., CHU, W-C. Effects of dietary omega-3 and omega -6 lipids and
vitamin E on serum cytokines, lipid mediators, and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr, v.18, p. 602-613, 1999.
WANG, J.C., et al. Development and prospect of rare earth functional biomaterials for agriculture in China Journal of Rare Earths, v.24, p. 427-431, 2006.
WEISBURGER, J.H. Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea. Food Chem Toxicol., v. 37, p. 943-8, 1999.
WILLIAMS, D.F. Dictionary of Biomaterials. Liverpool: Liverpool University Press p.42, 1999.
XIA, Z., JAMES, T.T. A review on macrophage responses to biomaterials. Biomed
Materials., v.1, p..1-9, 2006.
YAMADA, K., et al. Dietary effect of α–tocopherol and tocotrienols on lipid metabolism and immune function of aged Sprague-Dawley rats. Food Sci Technol Res., v.8, p. 59-63, 2002.
YOUNG, H-Y, et al. Analytical and stability studies of ginger preparations. J Food Drug Anal., v.10, p. 149-53, 2002.
